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郑广勇博士介绍(CO-PI)

 

2郑广勇,博士,副研究员。1995-1999年就读于上海华东理工大学生物化学工程学院/理学院,获学士学位;2000-2004年就读于中国科学院上海生命科学研究院,获硕士学位;2006-2009年就读于上海复旦大学生命科学学院/计算机科学技术学院,获博士学位。2013年-目前,中国科学院-马普学会计算生物学伙伴研究所,副研究员;上海生物信息技术研究中心,病原基因组学课题组,CO-PI. 郑广勇博士目前已在Nature genetics, PNAS, Human Mutation, Molecular & Cellular Proteomics, Bioinformatics, BMC bioinformatics,BMC genomics,  Nature communications 等国际重要学术刊物发表了一系列论文,论文总影响因子超过70,总引用次数超过400次。

【主要研究方向】
1. 全基因组规模上的基因定位及功能研究
2. 基于转录组学和表观基因组学数据的转录调控机制研究
3. 基于多种高通量组学数据的重大生理过程的系统生物学研究

【科研项目】
1. 2011.01- 2012.12,中国博士后科学基金面上项目“转录组蛋白质组数据整合算法的研究及分析平台的构建”,项目负责人;
2. 2012.01- 2012.12,国家自然科学基金青年基金项目“基于正向反向工程策略的哺乳动物转录调控关系研究”,项目负责人;
3. 2009.01-2010.12,中国科学院信息化专项项目“转录组-蛋白质组整合数据库的构建”,项目副组长;
4.2006.01-2008.12国家863高技术研究发展计划基金项目“转录因子结合位点及其组合模块的挖掘”,项目骨干;

【科研论文】
(1) Hong-xin Zhang et al. Guang-Yong Zheng, Yi-xue Li … Zhu-Guang Wang. Rig-I regulates NF-κB activity through binding to Nf-κb1 3′-UTR mRNA. PNAS 2013; 110(6): 6459–6464
 
(2) Guangyong Zheng, Qi Liu, Guohui Ding, Chaochun Wei, Yixue Li. Towards Biological Characters of Interactions between Transcription Factors and their DNA Targets in Mammals. BMC Genomics 2012, 13:388.

(3) Yupeng He, Yizhe Zhang, Guangyong Zheng, Chaochun Wei. CTF: a CRF-based transcription factor binding sites finding system. BMC Genomics 2012, 13(Suppl 8):S18. 

(4) The Bactrian Camels Genome Sequencing and Analysis Consortium. Genome sequences of wild and domestic bactrian camels. Nature Communications 2012;3:1202.

(5) Guangyong Zheng, Haibo Wang, Chaochun Wei, Yixue Li. iGepros: an integrated gene and protein annotation server for biological nature exploration. BMC Bioinformatics 2011 12(Suppl 14):S6.

(6) Yi–Bo Wu, Jie Dai, Xing–Lin Yang, Su–Jun Li, Shi–Lin Zhao, Jia–Shu Tang, Guang–Yong Zheng,Yi–Xue Li, Jia–Rui Wu, Rong Zeng. Concurrent Quantification of Proteome and Phosphoproteome to Reveal System–wide Association of Protein Phosphorylation and Gene Expression. Molecular & Cellular Proteomics 2009 Dec 8(12):2809–26.

(7) Guangyong Zheng, Hong Li, Chuan Wang, Quanhu Sheng, Haiwei Fan, Shaoyou Yang, Boshu Liu, Jianliang Dai, Rong Zeng, and Lu Xie. A platform to standardize, store, and visualize proteomics experimental data. Acta Biochimica et Biophysica Sinica 2009 Apr 41(4):273–9.

(8) Yun Xiong, Guangyong Zheng, Qing Yang, Yangyong Zhu. A Collaborative Multiagent System for Mining Transcriptional Regulatory Elements. IEEE Intelligent Systems 2009(24):26-37

(9) Guangyong Zheng, Kang Tu, Qing Yang, Yun Xiong, Chaochun Wei, Lu Xie, Yangyong Zhu and Yixue Li. “ITFP: an integrated platform of mammalian transcription factors”. Bioinformatics 2008 24(20):2416–2417.

(10) Guangyong Zheng, Ziliang Qian, Qing Yang, Chaochun Wei, Lu Xie, Yangyong Zhu, and Yixue Li. The combination approach of SVM and ECOC for powerful identification and classification of transcription factor. BMC Bioinformatics 2008 (9): 282.

(11) Shengcai Wei, Sen Yang, Da Lin, Ming Li, Xueqi Zhang, Lei Bu, Guangyong Zheng, Landian Hu, Xiangyin Kong and Xuejun Zhang. A Novel Locus for Disseminated Superficial Porokeratosis Maps to Chromosome 18p11.3. Journal of Investigative Dermatology 2004 (123): 872–875.

(12) Guangyong Zheng, Landian Hu, Wei Huang, Kaide Chen, Xuejun Zhang, Sen Yang, Jianfang Sun, Yiqun Jiang, Guangbin Luo, and Xiangyin Kong. CYLD Mutation Causes Multiple Familial Trichoepithelioma in Three Chinese Families. Human Mutation 2004 Apr 23(4):400.

(13) Landian Hu, Guangyong Zheng, Haisong Jiang, Yu Xia, Yi Zhang, Xiangyin Kong. Mutation analysis of 20 SARS virus genome sequences: evidence for negative selection in replicase ORF1b and spike gene. Acta Pharmacologica Sinica 2003 24(8):741-745.

(14) Lei Bu,Yiping Jin, et al. Guangyong Zheng, … Xiangyin Kong. Mutant DNA–binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. Nature Genetics 2002 (31): 276 – 278.

(15) Guangyong Zheng, Ming Yan, Li Zhou, Guoping Zhao and Yixue Li. Construction of a proteomic map database. Acta Biochimica et Biophysica Sinica 2002, 34(2): 209–214.

(16)  Shangxi Xiao, Lei Bu, Liqin Zhu, Guangyong Zheng, Minghua Yang, Meiqian Qian, Landian Hu, Jing Liu, Guoping Zhao and Xiangyin Kong. A New Locus for Hereditary Gingival Fibromatosis (GINGF2) Maps to 5q13–q22. Genomics 2001, 74(2): 180–185.