课题组长：谢鹭，博士，研究员，中心主任助理。2000年毕业于中南大学湘雅医学院。2000-2005美国范德堡大学博士后。2005.8-目前，上海生物信息技术研究中心。研究方向为转化医学与生物信息学。作为主要负责人承担863，973子课题等国家重大科研项目。上海市浦江人才。曾获湖南省科技进步二等奖。国内外已发表学术论文50多篇。
课题组研究方向： 应用医学（或译为转化医学，Translational Medicine）是一个新兴的多学科融合的领域。该领域的主旨在于促进基础医学研究向临床应用的转化，同时根据临床医学的需求提出前瞻性的应用基础研究方向。研究组成立于2005年10月。工作重点在于疾病分子标志物的生物统计学挖掘和生物信息学分析。主要内容包括：从大规模转录组和蛋白质组学实验数据中挖掘与疾病发生、发展、预后、疗效评估等相关的分子标志物群，并进行功能注释、预测和功能网络分析，以指导和促进疾病分子标志物的验证和应用。与国内外多家著名医学及生物研究机构建立了稳定合作联系。承担的项目以及研究方向包括：基于生物信息学的mRNA 和microRNA表达整合分析与肿瘤分子标记物网络；面向高通量定量蛋白质组学数据分析流程的协同软件（国家高科技863项目）；蛋白质组海量质谱数据解析及其在人类基因组注释中的应用(国家重大基础研究973项目)；磷酸化介导的细胞信号传递网络重构；并参与艾滋病和病毒性肝炎等重大传染病防治科技重大专项；等。部分研究成果发表于Science, Molecular and Cellular Proteomics, Nucleic Acids Research, Cancer Research, Bioinformatics, Journal of Proteome Research, BMC Bioinformatics, Journal of Translational Medicine, International Journal of Cancer等杂志上。
代表性论文（括号内为杂志5年期影响因子）：
1. Qijun Wang, Yakun Zhang, Chen Yang, Hui Xiong, Yan Lin, Jun Yao, Hong Li, Lu Xie, Wei Zhao, Yufeng Yao, Zhi-Bin Ning, Rong Zeng, Yue Xiong, Kun-Liang Guan, Shimin Zhao, and Guo-Ping Zhao. Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux. Science, 19 February 2010: 1004-1007. （30.0） 2. Hong Li, Ying He, Guohui Ding, Chuan Wang, Lu Xie* and Yixue Li*. dbDEPC: a database of Differentially Expressed Proteins in human Cancers. Nucleic Acids Research, 2009, doi:10.1093/nar/gkp933. *: 共同通讯作者 (6.968) 3. Kang Tu, Hui Yu, Youjia Hua, Yuan-Yuan Li, Lei Liu, Lu Xie*, Yixue Li*. Combinatorial network of primary and secondary microRNA-driven regulatory mechanisms. Nucleic Acids Research, 2009, 37 (18): 5969-5980. *:共同通讯作者 (6.968) 4. Hong Li, Xiaobin Xing, Guohui Ding, Qingrun Li, Chuan Wang, Lu Xie*, Rong Zeng*, Yixue Li*. SysPTM – a Systematic Resource for Proteomic Research of Post-translational Modifications. Molecular and Cellular Proteomics，2009, 8 (8): 1839-1849. *:共同通讯作者 (9.391) 5. Hong Li, Guohui Ding, Lu Xie*, Yixue Li*. PAnnBuilder: An R Package for Assembling Proteomic Annotation Data. Bioinformatics, 2009; doi: 10.1093/bioinformatics/btp100. *: 共同通讯作者 (6.481) 6. Songling Li, Hong Li, Mingfa Li, Yu Shyr, Lu Xie*, Yixue Li*. Improved Prediction of Lysine Acetylation by Support Vector Machines. Protein and Peptide Letters, 2009, 16(8): 977-983. *:共同通讯作者(1.135) 7. Guangyong Zheng; Hong Li; Chuan Wang; Quanhu Sheng; Haiwei Fan; Shaoyou Yang; Boshu Liu; Jianliang Dai; Rong Zeng; Lu Xie*. A platform to standardize, store, and visualize proteomics experimental data. Acta Biochimica et Biophysica Sinica, 2009; doi: 10.1093/abbs/gmp010. *: 通讯作者. (0.937) 8. Tao Huang , Kang Tu, Yu Shyr, Chao-Chun Wei, Lu Xie* and Yi-Xue Li*. The prediction of interferon treatment effects based on time series microarray gene expression profiles. Journal of Translational Medicine, 2008, 6:44. *: 共同通讯作者(2.917) 9. Wenxi Li#, Lu Xie#, Xianghuo He#, Jinjun Li#, Kang Tu, Lin Wei , Jun Wu, Yong Guo, Xi Ma, Pingping Zhang, Zhimei Pan, Xin Hu, Yingjun Zhao, Haiyang Xie, Guoping Jiang, Taoyang Chen, Jianneng Wang, Shusen Zheng, Jing Cheng, Dafang Wan, Shengli Yang, Yixue Li, Jianren Gu. MicroRNA Signatures in Hepatocellular Carcinoma Diagnostic and Prognostic Implications. International Journal of Cancer, 2008, 123(7):1616-1622. #：共同贡献者 (4.656) 10. 李虹，谢鹭*。 预测和鉴定蛋白质翻译后修饰的生物信息方法。现代生物医学进展, 2008，8（9）：1729-1735。通讯作者。 11. 王峰，谢鹭*。基因芯片探针注释的问题分析及解决方法综述。现代生物医学进展，2007，7（9）：1391-1394。通讯作者。 12. Lu Xie, Jonathan B. Xu, Agnes Gorska, Yu Shyr, Sara Schwartz, Nikki Cheng, Shawn Levy, Brian Bierie , Richard Caprioli, Harold Moses. Genomic and proteomic Analysis of Mammary Tumors Arising in Transgenic Mice. Journal of Proteome Research, 2005, 4: 2088-2098. (5.737) 13. Lu Xie, Brian Law, Anna Chytil, Kimberly Brown, Mary Aakre and Harold Moses. Activation of the Erk pathway is required for TGF-ß1-induced epithelial to mesenchymal transition in vitro. 2004. Neoplasia, 2004, 6(5): 603-610. (5.124) 14. Lu Xie, Brian K Law, Mary E Aakre, Mary Edgerton, Yu Shyr, Neil A Bhowmick and Harold L Moses. Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Research, 2003, 5: R187-R198 (DOI 10.1186/bcr640). (4.97) 15. Lu Xie, et al, Kaitai Yao. Identification of Differentially Expressed Genes in nasopharyngeal Carcinoma by means of Atlas™ Human Cancer cDNA Expression Array. Journal of Cancer Research and Clinical Oncology, 2000; 126(7): 400-406. (2.598) 16. Zhuang G, Brantley-Sieders DM, Vaught D, Yu J, Xie L, Wells S, Jackson D, Muraoka-Cook R, Arteaga C, Chen J. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Research, 2010 Jan 1; 70(1):299-308. (7.98) 17. Jun Wu, Qingchao Qiu, Lu Xie, Joseph Fullerton, Jian Yu, Yu Shyr, Alfred L George Jr and Yajun Yi. Web-based Interrogation of Gene Expression Signatures Using EXALT. BMC Bioinformatics, 2009, 10:420. (4.246) 18. Guangyong Zheng, Kang Tu, Qing Yang, Chaochun Wei, Lu Xie, Yangyong Zhu, Yixue Li. ITFP: an integrated platform of mammalian transcription factors. Bioinformatics, 2008, 24(20): 2416-2417. (6.481) 19. Guangyong Zheng, Ziliang Qian, Qing Yang, Chaochun Wei, Lu Xie, Yangyong Zhu, Yixue Li. The Combination Approach of SVM and ECOC for Powerful Identification and Classification of Transcription Factor. BMC Bioinformatics, 2008, 9:282.(4.246)
